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8/14/2014 12:28 A.M. ET

Lohse's next start uncertain after ankle injury

Right-hander exits game against Cubs after three innings, allowing four runs

CHICAGO -- Brewers starter Kyle Lohse left a start against the Cubs on Wednesday night after aggravating his previously-injured right ankle during a rough third inning, leaving his next start uncertain.

Lohse was hurt while striking out in the top of the inning with the Brewers already trailing, 2-0, and took the mound in the bottom of the frame to surrender back-to-back home runs to Javier Baez and Anthony Rizzo, and a single to Starlin Castro.

He drew a visit from manager Ron Roenicke and head athletic trainer Dan Wright but remained in the game, and struck out the final three batters of the inning while Marco Estrada began to warm up in the bullpen.

Estrada took over in the bottom of the fourth. Lohse remained winless since July 23.

The injury is considered by all parties to be a minor one, but a pitcher altering his mechanics can lead to trouble. Lohse tweaked the right ankle he originally rolled on Aug. 2 in St. Louis.

"I was really sore after the last start because I was making adjustments," Lohse said. "Last time I pitched I was throwing probably all upper body and today was probably the same. I probably could have kept going, but it's one of those things where you just have to be smart about that and not hurt something else."

Asked whether he was confident Lohse will make his next start on schedule, Brewers manager Ron Roenicke responded, "I'm not 'confident,' but I think he will."

The upcoming schedule works in the Brewers' favor. An off-day Monday either allows Lohse an extra day of rest before he pitches against the Blue Jays at Miller Park on Tuesday, or allows the Brewers to skip Lohse and simply use others on regular rest in that series. The team is then off again on Aug. 21 and 28.

The Brewers are already missing one starting pitcher, with Matt Garza on the disabled list with a left rib-cage strain. He is improving, Roenicke said earlier Wednesday, but has yet to resume throwing.

Adam McCalvy is a reporter for MLB.com. Read his blog, Brew Beat, and follow him on Twitter at @AdamMcCalvy. This story was not subject to the approval of Major League Baseball or its clubs.